Dr. Valeria Tiranti


Molecular Neurogenetics Unit
Mariani Foundation Center for the Study of Pediatric Mitochondrial Diseases

IRCCS Foundation Neurological Institute

Via Libero Temolo 4, 20126 Milano, ITALIA

Tel 02-23942633
Fax 02-23942619


University of Milan - Biology degree cum laude, 1989
University of Milan - Specialization in Medical Genetics cum laude, 2001.

Professional experiences

1989-1991: Post-doctoral fellow, Department of Biochemistry and Genetics, Istituto Neurologico "C. Besta", Milano.

1992-2002: Senior fellowship at Istituto Neurologico "C. Besta", Milano.

2002-present: Research Associate Professor (Dirigente Biologo), Unit of Molecular Neurogenetics, IRCCS Fondazione Istituto Neurologico "C Besta"

Professional interests

I (Valeria Tiranti) have a long-standing expertise in mitochondrial and metabolic disorders, including identification of disease genes, biochemical evaluation of the respiratory chain activities, molecular and cellular biology, and identification of pathogenetic mechanisms of diseases. My group performed the characterization of different mouse models and attempted pharmacological treatments in some of them. Recently we started a series of experiments devoted to the generation of neurons by direct reprogramming of fibroblasts derived from patients affected by neurodegenerative diseases associated with mitochondrial dysfunctions. Moreover, we are generating induced pluripotent stem cells (iPSCs) from fibroblasts of patients affected by neurodegenerative diseases and genetic optic atrophy.

Scientific Experience
Molecular and cellular Biology
Biochemistry and Genetics of mitochondrial disorders and in general of defects of bioenergetic metabolism
Biochemistry and Genetics of neurodegenerative disorders
In vivo and in vitro models of diseases